Detection and analysis of drug–drug interactions among hospitalized cardiac patients in the Mohammed V Military Teaching Hospital in Morocco
Identifieur interne : 000483 ( Main/Exploration ); précédent : 000482; suivant : 000484Detection and analysis of drug–drug interactions among hospitalized cardiac patients in the Mohammed V Military Teaching Hospital in Morocco
Auteurs : Hicham Fettah ; Youssef Moutaouakkil ; Mohamed Reda Sefrioui ; Badreddine Moukafih ; Yassir Bousliman ; Ahmed Bennana [Maroc] ; Jamal Lamsaouri [Maroc] ; Sanaa Makram ; Yahia CherrahSource :
- The Pan African Medical Journal [ 1937-8688 ] ; 2018.
Descripteurs français
- KwdFr :
- Adulte (MeSH), Adulte d'âge moyen (MeSH), Effets secondaires indésirables des médicaments (épidémiologie), Femelle (MeSH), Hospitalisation (MeSH), Humains (MeSH), Hôpitaux d'enseignement (MeSH), Hôpitaux militaires (MeSH), Interactions médicamenteuses (MeSH), Jeune adulte (MeSH), Maladies cardiovasculaires (traitement médicamenteux), Maroc (épidémiologie), Mâle (MeSH), Prévalence (MeSH), Sujet âgé (MeSH), Sujet âgé de 80 ans ou plus (MeSH), Études prospectives (MeSH).
- MESH :
- traitement médicamenteux : Maladies cardiovasculaires.
- épidémiologie : Effets secondaires indésirables des médicaments, Maroc.
- Adulte, Adulte d'âge moyen, Femelle, Hospitalisation, Humains, Hôpitaux d'enseignement, Hôpitaux militaires, Interactions médicamenteuses, Jeune adulte, Mâle, Prévalence, Sujet âgé, Sujet âgé de 80 ans ou plus, Études prospectives.
English descriptors
- KwdEn :
- Adult (MeSH), Aged (MeSH), Aged, 80 and over (MeSH), Cardiovascular Diseases (drug therapy), Drug Interactions (MeSH), Drug-Related Side Effects and Adverse Reactions (epidemiology), Female (MeSH), Hospitalization (MeSH), Hospitals, Military (MeSH), Hospitals, Teaching (MeSH), Humans (MeSH), Male (MeSH), Middle Aged (MeSH), Morocco (epidemiology), Prevalence (MeSH), Prospective Studies (MeSH), Young Adult (MeSH).
- MESH :
- drug therapy : Cardiovascular Diseases.
- epidemiology : Drug-Related Side Effects and Adverse Reactions, Morocco.
- Adult, Aged, Aged, 80 and over, Drug Interactions, Female, Hospitalization, Hospitals, Military, Hospitals, Teaching, Humans, Male, Middle Aged, Prevalence, Prospective Studies, Young Adult.
Abstract
Drug-drug interactions (DDIs) are defined as two or more drugs interacting in such a manner that the effectiveness or toxicity of one or more drugs is altered. Patients with cardiovascular disorders are at higher risk for DDIs because of the types and number of drugs they receive. The aim of the present study was to assess the prevalence of DDIs in patients admitted to the cardiology department of a hospital in Morocco.
A prospective observational study from June 2016 to September 2016 was carried out in the cardiology department of a hospital in Morocco. Those patients who were taking at least two drugs and had a hospital stay of at least 48 hours were included in the study. The medications of the patients were analysed for possible interactions. All the prescriptions of the study population were screened for drug-drug interactions using a computerized DDI database system (Theriaque®).
During the study period, 138 patients were included; 360 interactions were detected among 94 patients, with an average number of drugs taken of 5.2. The prevalence of DDIs was estimated at 68.11%, the most common of which concerned Kardegic/Plavix (12.22%), Kardegic/Heparin (8.33%), and Lasilix/Spironolactone (5.83%). Among the 726 prescribed drugs, (372 [51.24%]) were drugs of the cardiovascular system, followed by blood and hematopoietic organ drugs (288 [39.67%]) according to the Anatomical Therapeutic Chemical Classification codes. These interactions were categorized on the basis of level of severity: interactions with major severity accounted for 11.11% (40) of the total DDIs while those with moderate and minor severity accounted for 37.22% (134) and 51.66% (186), respectively.
This study reports the prevalence of DDIs in patients admitted to the cardiology department of a hospital in Morocco. This study shows that DDIs are frequent among hospitalized cardiac patients and highlights the need to screen prescriptions of cardiovascular patients for possible DDIs, as this helps in their detection and prevention.
Pan African Medical Journal – ISSN: 1937- 8688 (
Published in partnership with the African Field Epidemiology Network (AFENET). (
Pan African Medical Journal – ISSN: 1937- 8688 (
Published in partnership with the African Field Epidemiology Network (AFENET). (
Url:
DOI: 10.11604/pamj.2018.29.225.14169
PubMed: 30100979
PubMed Central: 6080962
Affiliations:
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Le document en format XML
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id="aff0001">Laboratory of Pharmacology, Toxicology, Faculty of Medicine and Pharmacy, Rabat Institute, University Mohamed V, Rabat-Morocco</nlm:aff><wicri:noCountry code="subfield">Rabat-Morocco</wicri:noCountry></affiliation></author><author><name sortKey="Moutaouakkil, Youssef" sort="Moutaouakkil, Youssef" uniqKey="Moutaouakkil Y" first="Youssef" last="Moutaouakkil">Youssef Moutaouakkil</name><affiliation><nlm:aff id="aff0001">Laboratory of Pharmacology, Toxicology, Faculty of Medicine and Pharmacy, Rabat Institute, University Mohamed V, Rabat-Morocco</nlm:aff><wicri:noCountry code="subfield">Rabat-Morocco</wicri:noCountry></affiliation></author><author><name sortKey="Sefrioui, Mohamed Reda" sort="Sefrioui, Mohamed Reda" uniqKey="Sefrioui M" first="Mohamed Reda" last="Sefrioui">Mohamed Reda Sefrioui</name><affiliation><nlm:aff id="aff0001">Laboratory of Pharmacology, Toxicology, Faculty of Medicine and Pharmacy, Rabat Institute, University Mohamed V, Rabat-Morocco</nlm:aff><wicri:noCountry code="subfield">Rabat-Morocco</wicri:noCountry></affiliation></author><author><name sortKey="Moukafih, Badreddine" sort="Moukafih, Badreddine" uniqKey="Moukafih B" first="Badreddine" last="Moukafih">Badreddine Moukafih</name><affiliation><nlm:aff id="aff0001">Laboratory of Pharmacology, Toxicology, Faculty of Medicine and Pharmacy, Rabat Institute, University Mohamed V, Rabat-Morocco</nlm:aff><wicri:noCountry code="subfield">Rabat-Morocco</wicri:noCountry></affiliation></author><author><name sortKey="Bousliman, Yassir" sort="Bousliman, Yassir" uniqKey="Bousliman Y" first="Yassir" last="Bousliman">Yassir Bousliman</name><affiliation><nlm:aff id="aff0001">Laboratory of Pharmacology, Toxicology, Faculty of Medicine and Pharmacy, Rabat Institute, University Mohamed V, Rabat-Morocco</nlm:aff><wicri:noCountry code="subfield">Rabat-Morocco</wicri:noCountry></affiliation></author><author><name sortKey="Bennana, Ahmed" sort="Bennana, Ahmed" uniqKey="Bennana A" first="Ahmed" last="Bennana">Ahmed Bennana</name><affiliation wicri:level="1"><nlm:aff id="aff0002">Laboratory of Medicinal Chemistry, Faculty of Medicine and Pharmacy, Rabat Institute, University Mohamed V, Rabat, Morocco</nlm:aff><country xml:lang="fr">Maroc</country><wicri:regionArea>Laboratory of Medicinal Chemistry, Faculty of Medicine and Pharmacy, Rabat Institute, University Mohamed V, Rabat</wicri:regionArea></affiliation></author><author><name sortKey="Lamsaouri, Jamal" sort="Lamsaouri, Jamal" uniqKey="Lamsaouri J" first="Jamal" last="Lamsaouri">Jamal Lamsaouri</name><affiliation wicri:level="1"><nlm:aff id="aff0002">Laboratory of Medicinal Chemistry, Faculty of Medicine and Pharmacy, Rabat Institute, University Mohamed V, Rabat, Morocco</nlm:aff><country xml:lang="fr">Maroc</country><wicri:regionArea>Laboratory of Medicinal Chemistry, Faculty of Medicine and Pharmacy, Rabat Institute, University Mohamed V, Rabat</wicri:regionArea></affiliation></author><author><name sortKey="Makram, Sanaa" sort="Makram, Sanaa" uniqKey="Makram S" first="Sanaa" last="Makram">Sanaa Makram</name><affiliation><nlm:aff id="aff0001">Laboratory of Pharmacology, Toxicology, Faculty of Medicine and Pharmacy, Rabat Institute, University Mohamed V, Rabat-Morocco</nlm:aff><wicri:noCountry code="subfield">Rabat-Morocco</wicri:noCountry></affiliation></author><author><name sortKey="Cherrah, Yahia" sort="Cherrah, Yahia" uniqKey="Cherrah Y" first="Yahia" last="Cherrah">Yahia Cherrah</name><affiliation><nlm:aff id="aff0001">Laboratory of Pharmacology, Toxicology, Faculty of Medicine and Pharmacy, Rabat Institute, University Mohamed V, Rabat-Morocco</nlm:aff><wicri:noCountry code="subfield">Rabat-Morocco</wicri:noCountry></affiliation></author></analytic><series><title level="j">The Pan African Medical Journal</title><idno type="eISSN">1937-8688</idno><imprint><date when="2018">2018</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adult (MeSH)</term><term>Aged (MeSH)</term><term>Aged, 80 and over (MeSH)</term><term>Cardiovascular Diseases (drug therapy)</term><term>Drug Interactions (MeSH)</term><term>Drug-Related Side Effects and Adverse Reactions (epidemiology)</term><term>Female (MeSH)</term><term>Hospitalization (MeSH)</term><term>Hospitals, Military (MeSH)</term><term>Hospitals, Teaching (MeSH)</term><term>Humans (MeSH)</term><term>Male (MeSH)</term><term>Middle Aged (MeSH)</term><term>Morocco (epidemiology)</term><term>Prevalence (MeSH)</term><term>Prospective Studies (MeSH)</term><term>Young Adult (MeSH)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Adulte (MeSH)</term><term>Adulte d'âge moyen (MeSH)</term><term>Effets secondaires indésirables des médicaments (épidémiologie)</term><term>Femelle (MeSH)</term><term>Hospitalisation (MeSH)</term><term>Humains (MeSH)</term><term>Hôpitaux d'enseignement (MeSH)</term><term>Hôpitaux militaires (MeSH)</term><term>Interactions médicamenteuses (MeSH)</term><term>Jeune adulte (MeSH)</term><term>Maladies cardiovasculaires (traitement médicamenteux)</term><term>Maroc (épidémiologie)</term><term>Mâle (MeSH)</term><term>Prévalence (MeSH)</term><term>Sujet âgé (MeSH)</term><term>Sujet âgé de 80 ans ou plus (MeSH)</term><term>Études prospectives (MeSH)</term></keywords><keywords scheme="MESH" qualifier="drug therapy" xml:lang="en"><term>Cardiovascular Diseases</term></keywords><keywords scheme="MESH" qualifier="epidemiology" xml:lang="en"><term>Drug-Related Side Effects and Adverse Reactions</term><term>Morocco</term></keywords><keywords scheme="MESH" qualifier="traitement médicamenteux" xml:lang="fr"><term>Maladies cardiovasculaires</term></keywords><keywords scheme="MESH" qualifier="épidémiologie" xml:lang="fr"><term>Effets secondaires indésirables des médicaments</term><term>Maroc</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Adult</term><term>Aged</term><term>Aged, 80 and over</term><term>Drug Interactions</term><term>Female</term><term>Hospitalization</term><term>Hospitals, Military</term><term>Hospitals, Teaching</term><term>Humans</term><term>Male</term><term>Middle Aged</term><term>Prevalence</term><term>Prospective Studies</term><term>Young Adult</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Adulte</term><term>Adulte d'âge moyen</term><term>Femelle</term><term>Hospitalisation</term><term>Humains</term><term>Hôpitaux d'enseignement</term><term>Hôpitaux militaires</term><term>Interactions médicamenteuses</term><term>Jeune adulte</term><term>Mâle</term><term>Prévalence</term><term>Sujet âgé</term><term>Sujet âgé de 80 ans ou plus</term><term>Études prospectives</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><sec id="s1"><title>Introduction</title><p>Drug-drug interactions (DDIs) are defined as two or more drugs interacting in such a manner that the effectiveness or toxicity of one or more drugs is altered. Patients with cardiovascular disorders are at higher risk for DDIs because of the types and number of drugs they receive. The aim of the present study was to assess the prevalence of DDIs in patients admitted to the cardiology department of a hospital in Morocco.</p></sec><sec id="s2"><title>Methods</title><p>A prospective observational study from June 2016 to September 2016 was carried out in the cardiology department of a hospital in Morocco. Those patients who were taking at least two drugs and had a hospital stay of at least 48 hours were included in the study. The medications of the patients were analysed for possible interactions. All the prescriptions of the study population were screened for drug-drug interactions using a computerized DDI database system (Theriaque<sup>®</sup>).</p></sec><sec id="s3"><title>Results</title><p>During the study period, 138 patients were included; 360 interactions were detected among 94 patients, with an average number of drugs taken of 5.2. The prevalence of DDIs was estimated at 68.11%, the most common of which concerned Kardegic/Plavix (12.22%), Kardegic/Heparin (8.33%), and Lasilix/Spironolactone (5.83%). Among the 726 prescribed drugs, (372 [51.24%]) were drugs of the cardiovascular system, followed by blood and hematopoietic organ drugs (288 [39.67%]) according to the Anatomical Therapeutic Chemical Classification codes. These interactions were categorized on the basis of level of severity: interactions with major severity accounted for 11.11% (40) of the total DDIs while those with moderate and minor severity accounted for 37.22% (134) and 51.66% (186), respectively.</p></sec><sec id="s4"><title>Conclusion</title><p>This study reports the prevalence of DDIs in patients admitted to the cardiology department of a hospital in Morocco. This study shows that DDIs are frequent among hospitalized cardiac patients and highlights the need to screen prescriptions of cardiovascular patients for possible DDIs, as this helps in their detection and prevention.</p><p>Pan African Medical Journal – ISSN: 1937- 8688 (<ext-link ext-link-type="uri" xlink:href="http://www.panafrican-med-journal.com">www.panafrican-med-journal.com</ext-link>)</p><p>Published in partnership with the African Field Epidemiology Network (AFENET). (<ext-link ext-link-type="uri" xlink:href="http://www.afenet.net">www.afenet.net</ext-link>)</p><p>Pan African Medical Journal – ISSN: 1937- 8688 (<ext-link ext-link-type="uri" xlink:href="http://www.panafrican-med-journal.com">www.panafrican-med-journal.com</ext-link>)</p><p>Published in partnership with the African Field Epidemiology Network (AFENET). (<ext-link ext-link-type="uri" xlink:href="http://www.afenet.net">www.afenet.net</ext-link>)</p></sec></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Leveque, D" uniqKey="Leveque D">D Levêque</name></author><author><name sortKey="Lemachatti, J" uniqKey="Lemachatti J">J Lemachatti</name></author><author><name sortKey="Nivoix, Y" uniqKey="Nivoix Y">Y Nivoix</name></author><author><name sortKey="Coliat, P" uniqKey="Coliat P">P Coliat</name></author><author><name sortKey="Santucci, R" uniqKey="Santucci R">R Santucci</name></author><author><name sortKey="Ubeaud Sequier, G" uniqKey="Ubeaud Sequier G">G Ubeaud-Séquier</name></author><author><name sortKey="Beretz, L" uniqKey="Beretz L">L Beretz</name></author><author><name sortKey="Vinzio, S" uniqKey="Vinzio S">S Vinzio</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Scheen, Andre" uniqKey="Scheen A">André 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sortKey="Beer, Jh" uniqKey="Beer J">JH Beer</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Aparasu, R" uniqKey="Aparasu R">R Aparasu</name></author><author><name sortKey="Baer, R" uniqKey="Baer R">R Baer</name></author><author><name sortKey="Aparasu, A" uniqKey="Aparasu A">A Aparasu</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Sharma, S" uniqKey="Sharma S">S Sharma</name></author><author><name sortKey="Chhetri, Hp" uniqKey="Chhetri H">HP Chhetri</name></author><author><name sortKey="Alam, K" uniqKey="Alam K">K Alam</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Riechelmann, Rp" uniqKey="Riechelmann R">RP Riechelmann</name></author><author><name sortKey="Moreira, F" uniqKey="Moreira F">F Moreira</name></author><author><name sortKey="Smaletz, O" uniqKey="Smaletz O">O Smaletz</name></author><author><name sortKey="Saad, Ed" uniqKey="Saad E">ED Saad</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Doubova, Sv" uniqKey="Doubova S">SV Doubova</name></author><author><name sortKey="Reyes Morales, H" uniqKey="Reyes Morales H">H Reyes-Morales</name></author><author><name sortKey="Torres Arreola Ldel, P" uniqKey="Torres Arreola Ldel P">P Torres-Arreola Ldel</name></author><author><name sortKey="Suarez Orteg, M" uniqKey="Suarez Orteg M">M Suarez- Orteg</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Bjorkman, Ik" uniqKey="Bjorkman I">IK Bjorkman</name></author><author><name sortKey="Fastbom, J" uniqKey="Fastbom J">J Fastbom</name></author><author><name sortKey="Schmidt, Ik" uniqKey="Schmidt I">IK Schmidt</name></author><author><name sortKey="Bernsten, Cb" uniqKey="Bernsten C">CB Bernsten</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Nightingle, Pg" uniqKey="Nightingle P">PG Nightingle</name></author><author><name sortKey="Adu, D" uniqKey="Adu D">D Adu</name></author><author><name sortKey="Richards, Nt" uniqKey="Richards N">NT Richards</name></author><author><name sortKey="Peters, M" uniqKey="Peters M">M Peters</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Smithburger, Pl" uniqKey="Smithburger P">PL Smithburger</name></author><author><name sortKey="Kane Gill, Sl" uniqKey="Kane Gill S">SL Kane-Gill</name></author><author><name sortKey="Seybert, Al" uniqKey="Seybert A">AL Seybert</name></author></analytic></biblStruct></listBibl></div1></back></TEI><affiliations><list><country><li>Maroc</li></country></list><tree><noCountry><name sortKey="Bousliman, Yassir" sort="Bousliman, Yassir" uniqKey="Bousliman Y" first="Yassir" last="Bousliman">Yassir Bousliman</name><name sortKey="Cherrah, Yahia" sort="Cherrah, Yahia" uniqKey="Cherrah Y" first="Yahia" last="Cherrah">Yahia Cherrah</name><name sortKey="Fettah, Hicham" sort="Fettah, Hicham" uniqKey="Fettah H" first="Hicham" last="Fettah">Hicham Fettah</name><name sortKey="Makram, Sanaa" sort="Makram, Sanaa" uniqKey="Makram S" first="Sanaa" last="Makram">Sanaa Makram</name><name sortKey="Moukafih, Badreddine" sort="Moukafih, Badreddine" uniqKey="Moukafih B" first="Badreddine" last="Moukafih">Badreddine Moukafih</name><name sortKey="Moutaouakkil, Youssef" sort="Moutaouakkil, Youssef" uniqKey="Moutaouakkil Y" first="Youssef" last="Moutaouakkil">Youssef Moutaouakkil</name><name sortKey="Sefrioui, Mohamed Reda" sort="Sefrioui, Mohamed Reda" uniqKey="Sefrioui M" first="Mohamed Reda" last="Sefrioui">Mohamed Reda Sefrioui</name></noCountry><country name="Maroc"><noRegion><name sortKey="Bennana, Ahmed" sort="Bennana, Ahmed" uniqKey="Bennana A" first="Ahmed" last="Bennana">Ahmed Bennana</name></noRegion><name sortKey="Lamsaouri, Jamal" sort="Lamsaouri, Jamal" uniqKey="Lamsaouri J" first="Jamal" last="Lamsaouri">Jamal Lamsaouri</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix 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